熊延，十大网投官方入口海峡研究院，教授，博士生导师。2012-2013年在美国哈佛大学医学院担任研究助理教授，2013年底回国加入中国科学院上海植物逆境生物学研究中心，研究员，并入选国家重大人才计划。2018年加入福建省十大网投官方入口海峡研究院组建植物营养与分子生物学实验室。主要从事植物营养和逆境信号转导研究，通过分子遗传学、系统生物学、基因组学、蛋白组学、代谢组学等手段，系统地研究内源营养信号和外源胁迫信号对植物生长发育的调控和影响。从事科研工作以来共发表研究论文及综述24篇。其中第一及责任作者文章16篇，他引超过2000次。其中代表性研究成果发表在 Nature， Molecular Cell, PNAS, Autophagy, COPB, Plant Journal, Plant Physiology等国际核心期刊上。

简历

熊延

教授，博士生导师

福建省十大网投官方入口海峡研究院

Email: yanxiong_fafu@163.com; Tel: 18516058622

学术荣誉：

2019十大网投官方入口 校内杰青培育

2019自然科学基金面上项目

2018高校拔尖人才人才项目（领军人才后备）

2017闽江学者特聘教授

2014国家重大人才计划

学历:

2006 美国爱荷华州立大学, 植物生理及分子生物学， 博士

2001 南开大学， 生物化学及分子生物学， 硕士

1998南开大学， 生物化学及分子生物学， 学士

工作经历：

2018-now, 教授，十大网投官方入口海峡研究院

2013-2017,  研究员,中科院上海植物逆境生物学研究中心

2012-2013, 研究助理教授，美国哈佛大学医学院

2006-2011, 博士后，美国哈佛大学医学院

Research Interest:

The main research interest of my laboratory is to understand how complex growth and developmental programs are controlled in response to diverse internal and environmental stimuli in multicellular organisms, which represent some of the most ancient and universal questions in biology. Specifically, we chose to delineate the multifaceted functions of target of rapamycin (TOR) as our major research projects. TOR kinase is an evolutionarily conserved master regulator that integrates nutrients and energy signaling to promote cell proliferation and growth. My laboratory plans to explore novel paradigms for the multifaceted TOR signaling links by uncovering the physiological functions of diverse TOR kinase phosphorylation targets focusing on transcriptional reprogramming in stem/progenitor cell proliferation and metabolic control. Given the novel TOR signaling mechanisms we have discovered in Arabidopsis and the remarkable conservation of this ancient “growth hub”, the proposed studies may illuminate unexplored functions of TOR in both plants and animals, and ultimately offer new possibilities for agricultural improvement and disease therapy.

主要论文：

1. Xinbo Yuan, Ping Xu, Yongdong Yu, Yan Xiong*(2020).Glucose-TOR signaling regulates PIN2 stability to orchestrate auxin gradient and cell expansion in Arabidopsis root. Proc Natl Acad Sci USA.10.1073/pnas.2015400117

2. Liwen Fu, Pengchen Wang, Yan Xiong*(2020). Target of Rapamycin Signaling in Plant Stress Responses. Plant Physiology. doi: 10.1104/pp.19.01214

3. Nan zhang, Yanyan Meng, Xu Li, Yu Zhou, Liuyin Ma, Liwen Fu, Markus Schwarzländer, Hongtao Liu, and Yan Xiong*(2019). Metabolite-mediated TOR signaling regulates the circadian clock in Arabidopsis. Proc Natl Acad Sci USA. 10.1073/pnas.1913095116.

4. Pengcheng Wang, Yang Zhao, Zhongpeng Li, Chuan-Chih Hsu, Xue Liu, Liwen Fu, Yueh-Ju Hou, Yanyan Du, Shaojun Xie, Chunguang Zhang, Jinghui Gao, Minjie Cao, Xiaosan Huang, Yingfang Zhu, Kai Tang, Xingang Wang, W. Andy Tao, Yan Xiong*, Jian-Kang Zhu (2018) Reciprocal regulation of the TOR kinase and ABA receptor balances plant growth and stress response. Molecular Cell 69:100-112.

5. Wenguo Cai, Xiaojuan Li, Yanlin Liu, Yaowei Wang, Yue Zhou, Tongda Xu & Yan Xiong* (2017). COP1 integrates light signals to ROP2 for cell cycle activation. Plant Signaling & Behavior, DOI: 10.1080/155923

6. Xiaojuan Li, Wenguo Cai, Yanlin Liu, Hui Li, Liwen Fu, Zengyu Liu, Lin Xu, Hongtao Liu, Tongda Xu*, and Yan Xiong* (2017) Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes. Proc Natl Acad Sci USA. 114:2765-2770.

7. Yan Xiong, Jen Sheen (2015) Novel links in the plant TOR kinase signaling network. Curr. Opin. Plant Biol. 28:83-91

8. Zhenyu Cheng, Jianfeng Li, Yajie Niu, Xuecheng Zhang, Owen Woody, Yan Xiong, Slavica Djonovic, Yves Millet, Jenifer Bush, Brendan McConkey, Jen Sheen and Frederick M. Ausubel (2015) Pathogen-secreted proteases activate a novel plant immune pathway. Nature. 521: 213-216.

9. Yan Xiong*, Jen Sheen* (2014) The role of target of rapamycin signaling networks in plant growth and metabolism. Plant Physiology, 164: 499-512.

10. Yan Xiong*, Jen Sheen (2013) Moving beyond translation, glucose-TOR signaling in the transcriptional control of cell cycle. Cell Cycle, 12(13), 1989.

11. Yan Xiong*, Matthew McCormack, Lei Li, Qi Hall, Chengbin Xiang, Jen Sheen* (2013) Glucose-TOR signalling orchestrates transcriptome reprogramming and meristem activation. Nature. 496: 181-186 (elected by Faculty of 1000).

12. Yan Xiong, Jen Sheen (2012) Rapamycin and glucose-target of rapamycin (TOR) signaling in plants. Journal of Biological Chemistry. 287, 2836-2842 (elected by Faculty of 1000)

13. Jianfeng Li, Jenifer Bush, Yan Xiong, Lei Li, Matthew McCormack (2011) Large-scale protein-protein interaction analysis in Arabidopsis mesophyll protoplasts by split firefly luciferase complementation. PLoS ONE 6(11): e27364 (elected by Faculty of 1000)

14. Yimo Liu*, Yan Xiong*, Diane C. Bassham (2009) Autophagy is required for plant tolerance of drought and salt stress. Autophagy, 5:954-963.

15. Sang-Dong Yoo, Young-Hee Cho, Guillaume Tena, Yan Xiong, Jen Sheen (2008) Dual control of nuclear EIN3 by bifurcate MAPK cascades in _C2H4 signalling. Nature, 451:789-795.

16. Jen Sheen, Ping He, Libo Shan, Yan Xiong, Guillaume Tena, Sangdong Yoo, Younghee Cho, Marie Boudsocq, Horim Lee (2008) Signaling specificity and complexity of MAPK cascades in plant innate immunity. Biology of Molecular Plant-Microbe Interactions, Chapter 86

17. Yan Xiong, Anthony L. Contento, Diane C. Bassham (2007) Disruption of autophagy results in constitutive oxidative stress in Arabidopsis. Autophagy, 3: 257-258.

18. Yan Xiong,Anthony L. Contento, Phan Quang Nguyen, Diane C. Bassham (2007)Degradation of oxidized proteins by autophagy during oxidative stress in Arabidopsis. Plant Physiology. 143: 291-299.

19. Yan Xiong, Anthony L. Contento,Diane C. Bassham. (2005) AtATG18a is required for the formation of autophagosomes during nutrient stress and senescence in Arabidopsis thaliana. Plant Journal. 42: 535-546.

20. Anthony L. Contento*, Yan Xiong*, Diane C. Bassham. (2005) Visualization of autophagy in Arabidopsis using the fluorescent dye monodansylcadaverine and a GFP-AtATG8e fusion protein. Plant Journal. 42:598-608. (*Equal contribution)

21. Wei-min Li, Qing-dai Liu, Yan Xiong, Shu-Fang Wang, Ning-ning Wang, Yong Wang (2003) Significant role of cytokinins in maintaining the life of fronds in Spirodela polyrrhiza. Journal of Plant Physiology and Molecular Biology. 29 (3): 215-220

22. Yan Xiong, Cuimin Liu, Shufang Wang, Ningning Wang, Yong Wang (2002) Chloroplast Genome and the Regulation of Chloroplast-encoded Gene Expression.Plant PhysiologyCommunications 38 (3):264-270

23. Cuimin Liu, Yan Xiong, Shufang Wang, Ningning Wang, Yong Wang (2002)cDNA Cloning and Expression of rbcS Gene in Spirodela polyrrhiza.Plant Physiology Communications 38(3): 221-225

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