Tongda Xu 徐通达

FAFU-UCR Joint Center   福农-加州大学河边分校联合中心

Haixia Institute of Science and Technology 海峡联合研究院

Fujian Agricultural and Forestry University  十大网投官方入口

Email: tdxu@sibs.ac.cn   

Research achievement:

Auxin has been considered as a key hormone in plant that can regulate every aspect of plant growth and development. Previous studies intensively illustrated that Auxin has been perceived by its receptor TIR1 in nucleus that can control gene transcription. In the meanwhile, auxin has been repeatedly implicated in regulating cellular responses through a non-transcriptional manner. Our work identified a transmembrane kinase family proteins (TMKs) that regulates cell morphogenesis through ROP signaling (2014 Science) by the potential binding with auxin binding protein 1(ABP1).  Recent work showed that this non-canonical auxin signaling regulates cell division activity through TOR kinase (2017 PNAS), cell division pattern through MPK signaling (2019 PNAS), and differential growth in apical hook development through non-canonical IAAs (2019 Nature). In the meanwhile, we also have illustrated a self-regulation mechanism of auxin biosynthesis through phosphorylation of TAA proteins by TMK (2019 Nature Communications). More interestingly, TMKs has also been implicated in regulating stress responses through ABA signaling (Submitted). Overall, we aim to investigate the non-transcriptional auxin signaling through TMK based mechanism or other mechanisms, and also figure out the complex roles of ABP1 and ABP1-like proteins in this non-canonical auxin signaling.  

Honors主要荣誉:

2010 CEPCEB Annual Outstanding Graduate Student

2009 College & Chancellor Dissertation Fellowship

2014 国家重大人才计划

2014 The National Outstanding Youth Fund  基金委优秀青年基金

2017 Minjiang Scholar 闽江学者特聘教授

2018高校拔尖人才项目（领军人才后备）

2019国家自然科学基金面上项目

2019十大网投官方入口 校内杰青培育项目

Education教育经历:

1999-2003  B.S     Peking University    Biological Science
北京大学  生物科学

2005-2010  Ph.D   UC-Riverside           Cell, Molecular & Development Biology
加州大学河边分校    细胞分子发育生物学

Research 工作经历:

2003-2005 Research Assistant       China Academy of Agricultural Sciences. China
中国农科院  实验助理

2011-2013 Young Investigator      Temasek Lifescience Laboratory Ltd.  Singapore

新加坡淡马锡生命科学研究院 青年研究员

2014-2017 Principal Investigator   Shanghai Center for Plant Stress Biology.  China

中科院上海植物逆境生物学研究中心 研究员
2017-Now  Professor                      Fujian Agriculture and Forest University. China
十大网投官方入口  教授

主要学术任职

2015 - 2019 China Society of Plant Biology  member of the board
中国植物生理生态分子生物学协会  理事

2019-至今  China Society of Plant Biology  member of the board

中国植物生理生态分子生物学协会  常务理事

2015 – 2017 Shanghai Society of Plant Biology  member of the board
上海植物生理生态分子生物学协会   理事

主要发表:

 Cao M^#, Chen R^#, Li P^#, Yu Y, Zheng R, Ge D, Zheng W, Wang X, Gu Y, Gelova Z, Friml J, Zhang H, Liu R, He J, Xu T* (2019) TMK1-mediated auxin signalling regulates differential growth of the apical hook. Nature, 568:240–243

 Huang R^#, Zheng R^#, HeJ^*, ZhouZ, WangJ, Xiong Y, Xu T^*(2019)Non-canonical auxin signaling regulates cell division patterns during lateral root development. Proc Natl Acad Sci USA. 116(42):21285-21290

 Wang Q^#, Qin G^#, Cao M, Chen R, He Y, Yang L, Zeng Z, Yu Y, Gu Y, Xing W, Tao A, and Xu T^*(2019) A phosphorylation-based switch controls TAA1-mediated auxin biosynthesis in plants. Nature Communications. Accepted

 Li X, Cai W, Liu Y, Li Y, Fu L, Liu Z, Xu L, Liu H, Xu T*, and Xiong Y* (2017) Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes. Proc Natl Acad Sci USA. 114:2765-2770.

 Liang H, Zhang Y, Martinez P, Rasmussen C, Xu T*,Yang Z* (2018) The Microtubule-Associated Protein IQ67 DOMAIN5 Modulates Microtubule Dynamics and Pavement Cell Shape , Plant Physiology, 2018.08, 177(4): 1555~1568 * Co-corresponding author

 Li X, Ma D, Lu X, Hu X, Huang R, Liang T, Xu T, Tobin E, Liu H.(2016) Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock , PLANT CELL, 2016.11, 28(11): 2755~2769

 Gu X, Xu T, He Y (2014) A Histone H3 Lysine-27 Methyltransferase Complex Represses Lateral Root Formation in Arabidopsis thaliana. Molecular Plant, 2014.6, 7(6): 977~988

Xu T, Dai N, Chen J, Nagawa S, Cao M, Li H, Zhou Z, Chen X, Rycke R, Rakusova H, Wang W, Jones A, Friml J, Patterson S, Bleecker A, Yang Z. (2014) Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling. Science, 343:1025-1028

Xu T, Wen M, Nagawa S, Fu Y, Chen JG, Wu MJ, Perrot-Rechenmann C, Friml J, Jones AM, Yang Z. (2010) Cell Surface- and Rho GTPase-Based Auxin Signaling Controls Cellular Interdigitation in Arabidopsis. Cell, 143:99-110

 Nagawa S*, Xu T*, Lin D, Dhonukshe P, Zhang X, Friml J, Scheres B, Fu Y, Yang Z. (2012) ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. PLOS Biology, 10:e1001299. *Co-First Author.

 Li H, Xu T, Lin D, Wen M, Xie M, Duclercq J, Bielach A, Kim J, Reddy GV, Zuo J, Benková E, Friml J, Guo H, Yang Z.. (2012) Cytokinin signaling regulates pavement cell morphogenesis in Arabidopsis. Cell Research, 2012.146:1038

 Lin D, Nagawa S, Chen J, Cao L, Chen X, Xu T, Li H, Dhonukshe P, Yamamuro C, Friml J, Scheres B, Fu Y and Yang Z. (2012) A ROP GTPase-Dependent Auxin Signaling Pathway Regulates the Subcellular Distribution of PIN2 in Arabidopsis Roots. Current Biology 22: 1319-1325.

Xu T. (2012) Rho GTPase Activity Analysis in Plant Cells. Plant Signalling Networks: Methods and Protocols Chapter 10:135-144

Xu T, Nagawa S, Yang Z. (2011) Uniform auxin triggers the Rho GTPase-dependent formation of interdigitation patterns in pavement cells. Small GTPases 2（4）:227-232

 Nagawa S, Xu T, Yang Z. (2010.12) RHO GTPase in plants: Conservation and invention of regulators and effectors. Small GTPases 1(2): 78-88

Fu Y, Xu T, Zhu L, Wen M, Yang Z. (2009) A ROP GTPase signaling pathway controls cortical microtubule ordering and cell expansion in Arabidopsis. Current Biology 19: 1827-1832